The performance will be their only UK show and they will be joined on the bill by the likes of Jake Bugg, Disclosure, Metronomy, Of Mice & Men and I Am Legion.
Blink-182's Mark Hoppus said: "I’m stoked to play Reading & Leeds 2014. It’s our fourth time playing the festivals, and we’re very honoured.
"The new year will see us in the studio preparing new music, getting ready to rock the fine people of the UK. Prepare for the fury."
The festival takes place over the 2014 August bank holiday weekend and for more information visit readingfestival.com or leedsfestival.com