Jane's Addiction, NOFX and Sixx:A.M are the top names among the new additions along with Alien Ant Farm and Amon Amarth.
Download Festival takes place at Donington Park across June 10th to 12th with tickets with Rammstein, Black Sabbath and Iron Maiden headlining.
Motorhead were also due to play until the death of frontman Lemmy Kilmister. As well as renaming the main stage, the festival's organisers are working with the band's management on a tribute and a Motorhead logo remains on the poster for a Friday slot.
Back to the new additions to the line-up, they will include Anti-Flag, Bury Tomorrow, Escape The Fate, Periphery, Electric Wizard, Monster Truck and Graveyard.
Municipal Waste, One OK Rock, Heck, Hill Valley High, Turbowolf, Grand Magus, Whiskey Myers, Cane Hill, Zoax, Danko Jones, Shvpes, The King Is Blind, Kadavar and As Lions are also on board.
Also joining them will be Slaves, Wage War, Palisades, Ashestoangels, The Kenneths, Muncie Girls, Reigning Days, Black Peaks, Strange Bones and Good Tiger.
Tickets for the event are on sale now at a special early bird rate until February 12th. Find out more at downloadfestival.co.uk